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Tongue abnormality

DOID EFO Endpoint Browser PheWeb

TONGUEABNORMALITY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K14
  • Hospital discharge: ICD-9 — 529
  • Hospital discharge: ICD-8 — 529
  • Cause of death: ICD-10 — K14
  • Cause of death: ICD-9 — 529
  • Cause of death: ICD-8 — 529

2 out of 7 registries used, show all original rules.

1988

4. Check minimum number of events

None

1988

5. Include endpoints

None

1988

6. Filter based on genotype QC (FinnGen only)

1907

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 K00-K14
Name in latin Morbi linguae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14364 9193 5115
Only index persons 13250 8656 4594
Unadjusted period prevalence (%)
Whole population 0.22 0.26 0.14
Only index persons 0.27 0.32 0.18
Median age at first event (years)
Whole population 57.72 59.61 54.28
Only index persons 57.54 59.29 54.24

-FinnGen-

Key figures

All Female Male
Number of individuals 1907 1288 619
Unadjusted period prevalence (%) 0.44 0.51 0.31
Median age at first event (years) 59.02 58.67 59.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint TONGUEABNORMALITY and mortality.

Females

Parameter HR [95% CI] p-value
TONGUEABNORMALITY 1.01 [0.92, 1.11] 0.844
Birth year 0.995 [0.99, 1.0] 0.198

During the follow-up period (1.1.1998 — 31.12.2019), 1280 out of 7837 females with TONGUEABNORMALITY died.

Males

Parameter HR [95% CI] p-value
TONGUEABNORMALITY 1.287 [1.14, 1.45] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 860 out of 3953 males with TONGUEABNORMALITY died.

Mortality risk

Mortality risk for people of age

years, who have TONGUEABNORMALITY.

N-year risk Females Males
1 0.09% 0.154%
5 0.613% 1.159%
10 1.581% 2.976%
15 2.907% 5.429%
20 5.079% 9.175%

Relationships between endpoints

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Index endpoint: TONGUEABNORMALITY – Tongue abnormality

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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