type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
465869 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
51229 |
4. Check minimum number of eventsNone |
51229 |
5. Include endpointsNone |
51229 |
6. Filter based on genotype QC (FinnGen only) |
49101 |
Control definitions (FinnGen only)
Control exclude
T2D
Control conditions
not PANCREATITIS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E10-E14
Name in latin
Diabetes (mellitus) [obesus/non obesus] adultorum
Type 2 diabetes, wide definition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 467928 | 222070 | 240592 |
| Only index persons | 355717 | 165583 | 190134 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.54 | 6.36 | 6.72 |
| Only index persons | 6.71 | 6.09 | 7.26 |
| Median age at first event (years) | |||
| Whole population | 68.98 | 71.95 | 66.24 |
| Only index persons | 67.56 | 70.26 | 65.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 49101 | 20517 | 28584 |
| Unadjusted period prevalence (%) | 11.72 | 8.06 | 14.36 |
| Median age at first event (years) | 64.73 | 64.10 | 65.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint T2D_WIDE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T2D_WIDE | 2.119 [1.95, 2.3] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 58602 out of 148160 females with T2D_WIDE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T2D_WIDE | 2.131 [1.95, 2.33] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 64310 out of 170293 males with T2D_WIDE died.
Mortality risk
Mortality risk for people of age
years, who have T2D_WIDE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.118% | 0.256% |
| 5 | 0.909% | 1.692% |
| 10 | 2.116% | 3.862% |
| 15 | 3.899% | 7.662% |
| 20 | 6.809% | 12.739% |
Relationships between endpoints
↥Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition
GWS hits: 154
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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