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Type 2 diabetes

E4_DM2

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E11
  • Cause of death: ICD-10 E11
  • Medicine purchases: ATC A10B

3 out of 7 registries used, show all original rules.

80686

4. Check minimum number of events

Min. number of events 3
80686

5. Include endpoints

82473

6. Filter based on genotype QC (FinnGen only)

79190

Control definitions (FinnGen only)

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9
Parent code in ICD-10 E10-E14

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 79190 35381 43809
Unadjusted period prevalence (%) 18.38 13.90 22.00
Median age at first event (years) 59.60 58.82 60.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: E4_DM2 – Type 2 diabetes

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).