No definition available.
Antihypertensive medication - note that there are other indications
RX_ANTIHYP
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
248649 |
4. Check minimum number of events
Min. number of events
3
|
248649 |
5. Include endpointsNone |
248649 |
6. Filter based on genotype QC (FinnGen only) |
240395 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF5
Antihypertensive medication - note that there are other indications
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2334599 | 1215225 | 1102476 |
| Only index persons | 2040159 | 1081643 | 958516 |
| Unadjusted period prevalence (%) | |||
| Whole population | 32.79 | 34.81 | 30.80 |
| Only index persons | 38.27 | 39.76 | 36.59 |
| Median age at first event (years) | |||
| Whole population | 57.85 | 58.94 | 56.51 |
| Only index persons | 56.16 | 57.07 | 55.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 240395 | 122707 | 117688 |
| Unadjusted period prevalence (%) | 53.54 | 48.19 | 59.11 |
| Median age at first event (years) | 54.30 | 52.46 | 56.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RX_ANTIHYP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_ANTIHYP | 0.891 [0.84, 0.95] | < 0.001 |
| Birth year | 0.998 [0.99, 1.0] | 0.496 |
During the follow-up period (1.1.1998 — 31.12.2019), 143742 out of 808782 females with RX_ANTIHYP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RX_ANTIHYP | 0.995 [0.93, 1.06] | 0.886 |
| Birth year | 0.988 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 148263 out of 757662 males with RX_ANTIHYP died.
Mortality risk
Mortality risk for people of age
years, who have RX_ANTIHYP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.071% | 0.14% |
| 5 | 0.42% | 0.87% |
| 10 | 1.084% | 2.296% |
| 15 | 2.231% | 4.492% |
| 20 | 4.044% | 7.782% |
Relationships between endpoints
↥Index endpoint: RX_ANTIHYP – Antihypertensive medication - note that there are other indications
GWS hits: 230
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data