rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4702 |
4. Check minimum number of eventsNone |
4702 |
5. Include endpointsNone |
4702 |
6. Filter based on genotype QC (FinnGen only) |
4589 |
Control definitions (FinnGen only)
Control exclude
STILL_ADULT
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified rheumatoid arthritis
based on the number of shared cases.
Similar with more cases:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 51998 | 36359 | 14963 |
| Only index persons | 33687 | 24467 | 9220 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.86 | 1.04 | 0.42 |
| Only index persons | 0.75 | 0.90 | 0.35 |
| Median age at first event (years) | |||
| Whole population | 56.20 | 55.97 | 56.80 |
| Only index persons | 53.67 | 53.16 | 55.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4589 | 3095 | 1494 |
| Unadjusted period prevalence (%) | 1.06 | 1.22 | 0.75 |
| Median age at first event (years) | 49.88 | 47.92 | 53.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_NOS | 2.12 [1.94, 2.32] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 4940 out of 13811 females with RHEUMA_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_NOS | 1.947 [1.72, 2.2] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2401 out of 5968 males with RHEUMA_NOS died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.212% | 0.378% |
| 5 | 0.938% | 2.043% |
| 10 | 2.544% | 5.011% |
| 15 | 4.981% | 9.583% |
| 20 | 8.681% | 15.777% |
Relationships between endpoints
↥Index endpoint: RHEUMA_NOS – Other/unspecified rheumatoid arthritis
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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