Other/unspecified rheumatoid arthritis

RHEUMA_NOS

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M06.8, M06.9
  • Hospital discharge: ICD-9 7148
  • Hospital discharge: ICD-8 7123[8-9]
  • Cause of death: ICD-10 M06.8, M06.9
  • Cause of death: ICD-9 7148
  • Cause of death: ICD-8 7123[8-9]

2 out of 7 registries used, show all original rules.

4702

4. Check minimum number of events

None

4702

5. Include endpoints

None

4702

6. Filter based on genotype QC (FinnGen only)

4589

Control definitions (FinnGen only)

Control exclude STILL_ADULT

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 51998 36359 14963
Only index persons 33687 24467 9220
Unadjusted period prevalence (%)
Whole population 0.86 1.04 0.42
Only index persons 0.75 0.90 0.35
Median age at first event (years)
Whole population 56.20 55.97 56.80
Only index persons 53.67 53.16 55.03

-FinnGen-

Key figures

All Female Male
Number of individuals 4589 3095 1494
Unadjusted period prevalence (%) 1.06 1.22 0.75
Median age at first event (years) 49.88 47.92 53.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint RHEUMA_NOS and mortality.

Females

Parameter HR [95% CI] p-value
RHEUMA_NOS 2.12 [1.94, 2.32] < 0.001
Birth year 0.992 [0.98, 1.0] 0.046

During the follow-up period (1.1.1998 — 31.12.2019), 4940 out of 13811 females with RHEUMA_NOS died.

Males

Parameter HR [95% CI] p-value
RHEUMA_NOS 1.947 [1.72, 2.2] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2401 out of 5968 males with RHEUMA_NOS died.

Mortality risk

Mortality risk for people of age

years, who have RHEUMA_NOS.

N-year risk Females Males
1 0.212% 0.378%
5 0.938% 2.043%
10 2.544% 5.011%
15 4.981% 9.583%
20 8.681% 15.777%

Relationships between endpoints

Index endpoint: RHEUMA_NOS – Other/unspecified rheumatoid arthritis

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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