No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1064 |
4. Check minimum number of eventsNone |
1064 |
5. Include endpointsNone |
1064 |
6. Filter based on genotype QC (FinnGen only) |
1010 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_SEPTICHE_PNEUMONIA
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
A40
Name in latin
Septic(h)aemia pneumococcica
Similar endpoints
↥List of similar endpoints to
Pneumococcal septicemia
based on the number of shared cases.
Similar with more cases:
- Pneumonia derived septicemia
- Pneumonia derived septicemia
- Septicaemia
- Other bacterial diseases
- COPD/asthma/ILD related pneumonia or pneumonia derived septicaemia
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14540 | 6399 | 8046 |
| Only index persons | 12041 | 5409 | 6632 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.18 | 0.22 |
| Only index persons | 0.23 | 0.20 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 40.52 | 39.46 | 41.06 |
| Only index persons | 36.59 | 36.71 | 36.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1010 | 449 | 561 |
| Unadjusted period prevalence (%) | 0.23 | 0.18 | 0.28 |
| Median age at first event (years) | 57.09 | 50.90 | 62.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PNEUMO_SEPTHICHE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PNEUMO_SEPTHICHE | 2.811 [2.33, 3.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 996 out of 4840 females with PNEUMO_SEPTHICHE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PNEUMO_SEPTHICHE | 3.457 [2.88, 4.14] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 5934 males with PNEUMO_SEPTHICHE died.
Mortality risk
Mortality risk for people of age
years, who have PNEUMO_SEPTHICHE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.271% | 0.64% |
| 5 | 1.424% | 3.663% |
| 10 | 3.592% | 8.811% |
| 15 | 7.108% | 16.967% |
| 20 | 12.402% | 26.779% |
Relationships between endpoints
↥Index endpoint: PNEUMO_SEPTHICHE – Pneumococcal septicemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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