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Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery

EFO Endpoint Browser PheWeb

P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P00-P04
  • Cause of death: ICD-10 — P00-P04

2 out of 7 registries used, show all original rules.

443

4. Check minimum number of events

None

443

5. Include endpoints

443

6. Filter based on genotype QC (FinnGen only)

402

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF4
Parent code in ICD-10 P
Name in latin Fetus et neonatus factoribus maternis atque complicationibus graviditatis, laborum et partus affectus

Similar endpoints

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List of similar endpoints to Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 43198 19780 23410
Only index persons 16855 7854 9001
Unadjusted period prevalence (%)
Whole population 0.61 0.57 0.65
Only index persons 0.32 0.29 0.34
Median age at first event (years)
Whole population 0.01 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 402 216 186
Unadjusted period prevalence (%) 0.09 0.08 0.09
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV and mortality.

Females

Parameter HR [95% CI] p-value
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV 1.511 [1.16, 1.97] 0.002
Birth year 0.998 [0.99, 1.01] 0.664

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 18172 females with P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV died.

Males

Parameter HR [95% CI] p-value
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV 1.458 [1.19, 1.79] < 0.001
Birth year 0.991 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 21554 males with P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV died.

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV.

N-year risk Females Males
1 0.105% 0.363%
5 0.922% 1.99%
10 2.39% 4.812%
15 4.726% 9.086%
20 8.271% 14.988%

Relationships between endpoints

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Index endpoint: P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV – Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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