No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
370 |
4. Check minimum number of eventsNone |
370 |
5. Include endpointsNone |
370 |
6. Filter based on genotype QC (FinnGen only) |
348 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Osteonecrosis due to drugs
based on the number of shared cases.
Similar with more cases:
- Osteonecrosis
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1822 | 909 | 908 |
| Only index persons | 1748 | 891 | 857 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 67.96 | 67.79 | 68.14 |
| Only index persons | 68.30 | 68.00 | 68.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 348 | 170 | 178 |
| Unadjusted period prevalence (%) | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | 70.12 | 69.61 | 70.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint OSTEON_DRUGS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTEON_DRUGS | 6.288 [4.04, 9.8] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.139 |
During the follow-up period (1.1.1998 — 31.12.2019), 259 out of 709 females with OSTEON_DRUGS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTEON_DRUGS | 7.082 [4.47, 11.23] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 697 males with OSTEON_DRUGS died.
Mortality risk
Mortality risk for people of age
years, who have OSTEON_DRUGS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.545% | 1.567% |
| 5 | 3.374% | 8.081% |
| 10 | 8.458% | 18.232% |
| 15 | 15.072% | 31.532% |
| 20 | 25.297% | 48.531% |
Relationships between endpoints
↥Index endpoint: OSTEON_DRUGS – Osteonecrosis due to drugs
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data