osteonecrosis: A none disease characterized by death of bone tissue due to a lack of blood supply.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1861 |
4. Check minimum number of eventsNone |
1861 |
5. Include endpointsNone |
1861 |
6. Filter based on genotype QC (FinnGen only) |
1788 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M86-M90
Name in latin
Osteonecrosis
Similar endpoints
↥List of similar endpoints to
Osteonecrosis
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11327 | 6119 | 5165 |
| Only index persons | 10640 | 5800 | 4840 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.14 |
| Only index persons | 0.20 | 0.21 | 0.18 |
| Median age at first event (years) | |||
| Whole population | 61.28 | 64.60 | 57.35 |
| Only index persons | 61.13 | 64.33 | 57.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1788 | 991 | 797 |
| Unadjusted period prevalence (%) | 0.39 | 0.39 | 0.40 |
| Median age at first event (years) | 61.84 | 61.88 | 61.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_OSTEONECROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OSTEONECROSIS | 1.752 [1.53, 2.01] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.683 |
During the follow-up period (1.1.1998 — 31.12.2019), 1026 out of 4709 females with M13_OSTEONECROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OSTEONECROSIS | 2.658 [2.26, 3.13] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1006 out of 4055 males with M13_OSTEONECROSIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_OSTEONECROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.449% |
| 5 | 1.153% | 2.442% |
| 10 | 2.694% | 6.224% |
| 15 | 5.315% | 11.334% |
| 20 | 9.126% | 18.844% |
Relationships between endpoints
↥Index endpoint: M13_OSTEONECROSIS – Osteonecrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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