Maternal care for other conditions predominantly related to pregnancy

O15_PREG_MATERN_CARE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O26
  • Hospital discharge: ICD-9 648
  • Hospital discharge: excluded ICD-9 6480
  • Cause of death: ICD-10 O26
  • Cause of death: ICD-9 648
  • Cause of death: excluded ICD-9 6480

2 out of 7 registries used, show all original rules.

9058

4. Check minimum number of events

None

9058

5. Include endpoints

None

9058

6. Filter based on genotype QC (FinnGen only)

8626

Control definitions (FinnGen only)

Control exclude O15_PREG_OTHER_MAT_DISORD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O20-O29
Name in latin Cura aliarum condicionum maternarum praesertim ad graviditatem pertinentium

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 67323 67323 -
Only index persons 66389 66389 -
Unadjusted period prevalence (%)
Whole population 1.93 1.93 -
Only index persons 2.44 2.44 -
Median age at first event (years)
Whole population - 30.22 -
Only index persons - 30.20 -

-FinnGen-

Key figures

All Female Male
Number of individuals 8626 8626 -
Unadjusted period prevalence (%) 3.39 3.39 -
Median age at first event (years) 30.54 30.54 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_PREG_MATERN_CARE and mortality.

Females

Parameter HR [95% CI] p-value
O15_PREG_MATERN_CARE 0.815 [0.69, 0.97] 0.021
Birth year 0.993 [0.98, 1.0] 0.154

During the follow-up period (1.1.1998 — 31.12.2019), 239 out of 42826 females with O15_PREG_MATERN_CARE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_PREG_MATERN_CARE.

N-year risk Females Males
1 0.066% No data
5 0.455% No data
10 1.039% No data
15 2.12% No data
20 3.927% No data

Relationships between endpoints

Index endpoint: O15_PREG_MATERN_CARE – Maternal care for other conditions predominantly related to pregnancy

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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