No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
76340 |
4. Check minimum number of eventsNone |
76340 |
5. Include endpoints |
77578 |
6. Filter based on genotype QC (FinnGen only) |
74555 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF5
Pregnancy with abortive outcome
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 665419 | 665419 | - |
| Only index persons | 640469 | 640469 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 19.06 | 19.06 | - |
| Only index persons | 23.55 | 23.55 | - |
| Median age at first event (years) | |||
| Whole population | - | 27.25 | - |
| Only index persons | - | 27.16 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 74555 | 74555 | - |
| Unadjusted period prevalence (%) | 29.28 | 29.28 | - |
| Median age at first event (years) | 27.50 | 27.50 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_PREG_ABORT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_PREG_ABORT | 0.826 [0.74, 0.92] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.291 |
During the follow-up period (1.1.1998 — 31.12.2019), 1999 out of 259017 females with O15_PREG_ABORT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_PREG_ABORT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | No data |
| 5 | 0.499% | No data |
| 10 | 1.237% | No data |
| 15 | 2.398% | No data |
| 20 | 4.276% | No data |
Relationships between endpoints
↥Index endpoint: O15_PREG_ABORT – Pregnancy with abortive outcome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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