Medical abortion

O15_ABORT_MEDICAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O04
  • Hospital discharge: ICD-9 635
  • Hospital discharge: ICD-8 64[01]
  • Cause of death: ICD-10 O04
  • Cause of death: ICD-9 635
  • Cause of death: ICD-8 64[01]

2 out of 7 registries used, show all original rules.

45672

4. Check minimum number of events

None

45672

5. Include endpoints

None

45672

6. Filter based on genotype QC (FinnGen only)

43819

Control definitions (FinnGen only)

Control exclude O15_PREG_ABORT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O00-O08
Name in latin Abortus medicinalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 413370 413370 -
Only index persons 395127 395127 -
Unadjusted period prevalence (%)
Whole population 11.84 11.84 -
Only index persons 14.53 14.53 -
Median age at first event (years)
Whole population - 24.96 -
Only index persons - 24.82 -

-FinnGen-

Key figures

All Female Male
Number of individuals 43819 43819 -
Unadjusted period prevalence (%) 17.21 17.21 -
Median age at first event (years) 25.01 25.01 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_ABORT_MEDICAL and mortality.

Females

Parameter HR [95% CI] p-value
O15_ABORT_MEDICAL 1.193 [1.06, 1.34] 0.003
Birth year 0.992 [0.98, 1.0] 0.049

During the follow-up period (1.1.1998 — 31.12.2019), 1349 out of 148808 females with O15_ABORT_MEDICAL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ABORT_MEDICAL.

N-year risk Females Males
1 0.126% No data
5 0.649% No data
10 1.661% No data
15 3.135% No data
20 5.46% No data

Relationships between endpoints

Index endpoint: O15_ABORT_MEDICAL – Medical abortion

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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