Postpartum haemorrhage due to retained placenta

O15_POSTPART_HAEMORRH_PLACENTA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O72.0
  • Hospital discharge: ICD-9 6660
  • Cause of death: ICD-10 O72.0
  • Cause of death: ICD-9 6660

2 out of 7 registries used, show all original rules.

4955

4. Check minimum number of events

None

4955

5. Include endpoints

None

4955

6. Filter based on genotype QC (FinnGen only)

4760

Control definitions (FinnGen only)

Extra metadata

First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37145 37145 -
Only index persons 36716 36716 -
Unadjusted period prevalence (%)
Whole population 1.06 1.06 -
Only index persons 1.35 1.35 -
Median age at first event (years)
Whole population - 30.09 -
Only index persons - 30.08 -

-FinnGen-

Key figures

All Female Male
Number of individuals 4760 4760 -
Unadjusted period prevalence (%) 1.87 1.87 -
Median age at first event (years) 30.44 30.44 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_POSTPART_HAEMORRH_PLACENTA and mortality.

Females

Parameter HR [95% CI] p-value
O15_POSTPART_HAEMORRH_PLACENTA 0.584 [0.46, 0.74] < 0.001
Birth year 0.994 [0.99, 1.0] 0.144

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 19150 females with O15_POSTPART_HAEMORRH_PLACENTA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_POSTPART_HAEMORRH_PLACENTA.

N-year risk Females Males
1 0.043% No data
5 0.36% No data
10 0.906% No data
15 1.602% No data
20 2.71% No data

Relationships between endpoints

Index endpoint: O15_POSTPART_HAEMORRH_PLACENTA – Postpartum haemorrhage due to retained placenta

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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