Postpartum haemorrhage due to anatomy

O15_POSTPART_HAEMORRH_ANATOMY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O72.1
  • Hospital discharge: ICD-9 6661
  • Cause of death: ICD-10 O72.1
  • Cause of death: ICD-9 6661

2 out of 7 registries used, show all original rules.

4108

4. Check minimum number of events

None

4108

5. Include endpoints

None

4108

6. Filter based on genotype QC (FinnGen only)

3908

Control definitions (FinnGen only)

Extra metadata

First used in FinnGen datafreeze DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 29763 29763 -
Only index persons 29492 29492 -
Unadjusted period prevalence (%)
Whole population 0.85 0.85 -
Only index persons 1.08 1.08 -
Median age at first event (years)
Whole population - 30.31 -
Only index persons - 30.30 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3908 3908 -
Unadjusted period prevalence (%) 1.53 1.53 -
Median age at first event (years) 30.59 30.59 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_POSTPART_HAEMORRH_ANATOMY and mortality.

Females

Parameter HR [95% CI] p-value
O15_POSTPART_HAEMORRH_ANATOMY 0.525 [0.4, 0.68] < 0.001
Birth year 0.996 [0.99, 1.0] 0.323

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 21640 females with O15_POSTPART_HAEMORRH_ANATOMY died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_POSTPART_HAEMORRH_ANATOMY.

N-year risk Females Males
1 0.046% No data
5 0.315% No data
10 0.742% No data
15 1.405% No data
20 2.702% No data

Relationships between endpoints

Index endpoint: O15_POSTPART_HAEMORRH_ANATOMY – Postpartum haemorrhage due to anatomy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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