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Obstructed labour due to maternal pelvic abnormality

EFO MESH Endpoint Browser PheWeb

O15_LABOUR_PELVIC_ABNORM

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O65
  • Hospital discharge: ICD-9 — 653[0-4]
  • Hospital discharge: ICD-8 — 654
  • Cause of death: ICD-10 — O65
  • Cause of death: ICD-9 — 653[0-4]
  • Cause of death: ICD-8 — 654

2 out of 7 registries used, show all original rules.

5890

4. Check minimum number of events

None

5890

5. Include endpoints

None

5890

6. Filter based on genotype QC (FinnGen only)

5705

Control definitions (FinnGen only)

Control exclude O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O60-O75
Name in latin Obstructio partus ex abnormitate pelvis maternae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 47263 47263 -
Only index persons 45844 45844 -
Unadjusted period prevalence (%)
Whole population 1.35 1.35 -
Only index persons 1.69 1.69 -
Median age at first event (years)
Whole population - 28.54 -
Only index persons - 28.50 -

-FinnGen-

Key figures

All Female Male
Number of individuals 5705 5705 -
Unadjusted period prevalence (%) 2.24 2.24 -
Median age at first event (years) 28.35 28.35 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_LABOUR_PELVIC_ABNORM and mortality.

Females

Parameter HR [95% CI] p-value
O15_LABOUR_PELVIC_ABNORM 0.671 [0.52, 0.87] 0.003
Birth year 0.997 [0.99, 1.01] 0.449

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 9300 females with O15_LABOUR_PELVIC_ABNORM died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_PELVIC_ABNORM.

N-year risk Females Males
1 0.076% No data
5 0.429% No data
10 1.133% No data
15 2.244% No data
20 3.742% No data

Relationships between endpoints

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Index endpoint: O15_LABOUR_PELVIC_ABNORM – Obstructed labour due to maternal pelvic abnormality

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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