Obstructed labour due to malposition and malpresentation of fetus

O15_LABOUR_MALPOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O64
  • Hospital discharge: ICD-9 652
  • Cause of death: ICD-10 O64
  • Cause of death: ICD-9 652

2 out of 7 registries used, show all original rules.

9786

4. Check minimum number of events

None

9786

5. Include endpoints

None

9786

6. Filter based on genotype QC (FinnGen only)

9426

Control definitions (FinnGen only)

Control exclude O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O60-O75
Name in latin Obstructio partus e malpositione sive malpraesentatione fetus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 79613 79613 -
Only index persons 78589 78589 -
Unadjusted period prevalence (%)
Whole population 2.28 2.28 -
Only index persons 2.89 2.89 -
Median age at first event (years)
Whole population - 29.86 -
Only index persons - 29.84 -

-FinnGen-

Key figures

All Female Male
Number of individuals 9426 9426 -
Unadjusted period prevalence (%) 3.70 3.70 -
Median age at first event (years) 29.96 29.96 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_LABOUR_MALPOS and mortality.

Females

Parameter HR [95% CI] p-value
O15_LABOUR_MALPOS 0.56 [0.47, 0.67] < 0.001
Birth year 0.998 [0.99, 1.01] 0.607

During the follow-up period (1.1.1998 — 31.12.2019), 204 out of 45165 females with O15_LABOUR_MALPOS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_MALPOS.

N-year risk Females Males
1 0.083% No data
5 0.367% No data
10 0.858% No data
15 1.738% No data
20 3.159% No data

Relationships between endpoints

Index endpoint: O15_LABOUR_MALPOS – Obstructed labour due to malposition and malpresentation of fetus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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