Labour and delivery complicated by fetal stress [distress]

O15_LABOUR_FETAL_STRESS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O68
  • Cause of death: ICD-10 O68

2 out of 7 registries used, show all original rules.

11365

4. Check minimum number of events

None

11365

5. Include endpoints

None

11365

6. Filter based on genotype QC (FinnGen only)

10796

Control definitions (FinnGen only)

Control exclude O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O60-O75
Name in latin Labores et partus a molimine fetus complicati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 95101 95101 -
Only index persons 94499 94499 -
Unadjusted period prevalence (%)
Whole population 2.72 2.72 -
Only index persons 3.47 3.47 -
Median age at first event (years)
Whole population - 30.21 -
Only index persons - 30.21 -

-FinnGen-

Key figures

All Female Male
Number of individuals 10796 10796 -
Unadjusted period prevalence (%) 4.24 4.24 -
Median age at first event (years) 30.87 30.87 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_LABOUR_FETAL_STRESS and mortality.

Females

Parameter HR [95% CI] p-value
O15_LABOUR_FETAL_STRESS 0.602 [0.51, 0.71] < 0.001
Birth year 1.0 [0.99, 1.01] 0.965

During the follow-up period (1.1.1998 — 31.12.2019), 384 out of 83947 females with O15_LABOUR_FETAL_STRESS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_LABOUR_FETAL_STRESS.

N-year risk Females Males
1 0.074% No data
5 0.398% No data
10 1.03% No data
15 1.958% No data
20 3.628% No data

Relationships between endpoints

Index endpoint: O15_LABOUR_FETAL_STRESS – Labour and delivery complicated by fetal stress [distress]

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data