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Gestational [pregnancy-induced] oedema and proteinuria without hypertension

EFO MESH Endpoint Browser PheWeb

O15_GESTAT_OEDEM_PREINUR

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O12
  • Hospital discharge: ICD-9 — 646[12]A
  • Hospital discharge: ICD-8 — 6370[02]
  • Cause of death: ICD-10 — O12
  • Cause of death: ICD-9 — 646[12]A
  • Cause of death: ICD-8 — 6370[02]

2 out of 7 registries used, show all original rules.

3285

4. Check minimum number of events

None

3285

5. Include endpoints

None

3285

6. Filter based on genotype QC (FinnGen only)

3158

Control definitions (FinnGen only)

Control exclude O15_OEDEM_PROTUR_HYPERT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O10-O16
Name in latin Oedema et proteinuria gravidarum sine hypertensione

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26938 26938 -
Only index persons 25995 25995 -
Unadjusted period prevalence (%)
Whole population 0.77 0.77 -
Only index persons 0.96 0.96 -
Median age at first event (years)
Whole population - 27.57 -
Only index persons - 27.52 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3158 3158 -
Unadjusted period prevalence (%) 1.24 1.24 -
Median age at first event (years) 27.66 27.66 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_GESTAT_OEDEM_PREINUR and mortality.

Females

Parameter HR [95% CI] p-value
O15_GESTAT_OEDEM_PREINUR 0.781 [0.61, 1.0] 0.049
Birth year 1.0 [0.99, 1.01] 0.905

During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 9505 females with O15_GESTAT_OEDEM_PREINUR died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_GESTAT_OEDEM_PREINUR.

N-year risk Females Males
1 0.092% No data
5 0.551% No data
10 1.401% No data
15 2.607% No data
20 4.687% No data

Relationships between endpoints

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Index endpoint: O15_GESTAT_OEDEM_PREINUR – Gestational [pregnancy-induced] oedema and proteinuria without hypertension

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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