Failed induction of labour

O15_FAILED_INDUCT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O61
  • Hospital discharge: ICD-9 659[0-1]
  • Cause of death: ICD-10 O61
  • Cause of death: ICD-9 659[0-1]

2 out of 7 registries used, show all original rules.

2090

4. Check minimum number of events

None

2090

5. Include endpoints

None

2090

6. Filter based on genotype QC (FinnGen only)

1964

Control definitions (FinnGen only)

Control exclude O15_COMPLIC_LAB_DELIV

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O60-O75
Name in latin Tentamen inductionis laborum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14576 14576 -
Only index persons 14427 14427 -
Unadjusted period prevalence (%)
Whole population 0.42 0.42 -
Only index persons 0.53 0.53 -
Median age at first event (years)
Whole population - 31.09 -
Only index persons - 31.06 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1964 1964 -
Unadjusted period prevalence (%) 0.77 0.77 -
Median age at first event (years) 31.45 31.45 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_FAILED_INDUCT and mortality.

Females

Parameter HR [95% CI] p-value
O15_FAILED_INDUCT 0.685 [0.51, 0.92] 0.012
Birth year 1.001 [0.99, 1.01] 0.743

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 10535 females with O15_FAILED_INDUCT died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_FAILED_INDUCT.

N-year risk Females Males
1 0.077% No data
5 0.481% No data
10 1.265% No data
15 2.423% No data
20 4.321% No data

Relationships between endpoints

Index endpoint: O15_FAILED_INDUCT – Failed induction of labour

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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