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Excessive vomiting in pregnancy

EFO MESH Endpoint Browser PheWeb

O15_EXCESS_VOMIT_PREG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O21
  • Hospital discharge: ICD-9 — 643
  • Hospital discharge: ICD-8 — 638
  • Cause of death: ICD-10 — O21
  • Cause of death: ICD-9 — 643
  • Cause of death: ICD-8 — 638

2 out of 7 registries used, show all original rules.

3147

4. Check minimum number of events

None

3147

5. Include endpoints

None

3147

6. Filter based on genotype QC (FinnGen only)

2961

Control definitions (FinnGen only)

Control exclude O15_PREG_OTHER_MAT_DISORD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O20-O29
Name in latin Hyperemesis gravidarum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24039 24039 -
Only index persons 23527 23527 -
Unadjusted period prevalence (%)
Whole population 0.69 0.69 -
Only index persons 0.86 0.86 -
Median age at first event (years)
Whole population - 27.49 -
Only index persons - 27.48 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2961 2961 -
Unadjusted period prevalence (%) 1.16 1.16 -
Median age at first event (years) 27.66 27.66 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_EXCESS_VOMIT_PREG and mortality.

Females

Parameter HR [95% CI] p-value
O15_EXCESS_VOMIT_PREG 0.85 [0.65, 1.11] 0.227
Birth year 0.995 [0.98, 1.01] 0.484

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 13150 females with O15_EXCESS_VOMIT_PREG died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_EXCESS_VOMIT_PREG.

N-year risk Females Males
1 0.097% No data
5 0.459% No data
10 1.214% No data
15 2.523% No data
20 4.488% No data

Relationships between endpoints

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Index endpoint: O15_EXCESS_VOMIT_PREG – Excessive vomiting in pregnancy

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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