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Excessive, frequent and irregular menstruation

EFO MESH Endpoint Browser PheWeb

N14_MESNRUIRREG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N92
  • Hospital discharge: ICD-9 — 626[2-6]|6270
  • Hospital discharge: ICD-8 — 6262|6264
  • Hospital discharge: excluded ICD-9 — 6267
  • Cause of death: ICD-10 — N92
  • Cause of death: ICD-9 — 626[2-6]|6270
  • Cause of death: ICD-8 — 6262|6264
  • Cause of death: excluded ICD-9 — 6267

2 out of 7 registries used, show all original rules.

43710

4. Check minimum number of events

None

43710

5. Include endpoints

47061

6. Filter based on genotype QC (FinnGen only)

45284

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N80-N98
Name in latin Menstruatio abundans, frequens et irregularis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 349368 349368 -
Only index persons 324188 324188 -
Unadjusted period prevalence (%)
Whole population 10.01 10.01 -
Only index persons 11.92 11.92 -
Median age at first event (years)
Whole population - 43.83 -
Only index persons - 43.39 -

-FinnGen-

Key figures

All Female Male
Number of individuals 45284 45284 -
Unadjusted period prevalence (%) 17.79 17.79 -
Median age at first event (years) 42.94 42.94 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_MESNRUIRREG and mortality.

Females

Parameter HR [95% CI] p-value
N14_MESNRUIRREG 1.037 [0.95, 1.13] 0.399
Birth year 0.997 [0.99, 1.0] 0.388

During the follow-up period (1.1.1998 — 31.12.2019), 5512 out of 172260 females with N14_MESNRUIRREG died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_MESNRUIRREG.

N-year risk Females Males
1 0.102% No data
5 0.602% No data
10 1.553% No data
15 3.189% No data
20 5.755% No data

Relationships between endpoints

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Index endpoint: N14_MESNRUIRREG – Excessive, frequent and irregular menstruation

GWS hits: 15

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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