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Menorrhagia

EFO Endpoint Browser PheWeb

N14_MENORRHAGIA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N92.0
  • Hospital discharge: ICD-9 — 6262A|6262B|6266A
  • Hospital discharge: ICD-8 — 626[67]
  • Cause of death: ICD-10 — N92.0
  • Cause of death: ICD-9 — 6262A|6262B|6266A
  • Cause of death: ICD-8 — 626[67]

2 out of 7 registries used, show all original rules.

27026

4. Check minimum number of events

None

27026

5. Include endpoints

None

27026

6. Filter based on genotype QC (FinnGen only)

26066

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 206548 206548 -
Only index persons 186332 186332 -
Unadjusted period prevalence (%)
Whole population 5.92 5.92 -
Only index persons 6.85 6.85 -
Median age at first event (years)
Whole population - 44.18 -
Only index persons - 43.60 -

-FinnGen-

Key figures

All Female Male
Number of individuals 26066 26066 -
Unadjusted period prevalence (%) 10.24 10.24 -
Median age at first event (years) 42.79 42.79 -

-FinRegistry-

Age distribution of first events

01020304050607080900k10k20k30k40k50k60k70k80k90k100kAgeIndividuals

-FinnGen-

Age distribution of first events

02030405060700k1k2k3k4k5k6k7k8k9k10k11k12k13kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k2k4k6k8k10k12k14k16k18k20k22k24k26kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

0102030405060708090100012345678910AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

010203040506070809010001234567891011121314AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint N14_MENORRHAGIA and mortality.

Females

Parameter HR [95% CI] p-value
N14_MENORRHAGIA 0.887 [0.81, 0.98] 0.013
Birth year 0.999 [0.99, 1.01] 0.816

During the follow-up period (1.1.1998 — 31.12.2019), 2094 out of 77366 females with N14_MENORRHAGIA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_MENORRHAGIA.

N-year risk Females Males
1 0.109% No data
5 0.566% No data
10 1.483% No data
15 2.813% No data
20 4.991% No data

Relationships between endpoints

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Index endpoint: N14_MENORRHAGIA – Menorrhagia

GWS hits: 13

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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