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Hypertrophy of breast in women and men

Endpoint Browser PheWeb

N14_HYPERTROPHYBREAST_BOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N62
  • Hospital discharge: ICD-9 — 6111
  • Hospital discharge: ICD-8 — 6111
  • Cause of death: ICD-10 — N62
  • Cause of death: ICD-9 — 6111
  • Cause of death: ICD-8 — 6111

2 out of 7 registries used, show all original rules.

7920

4. Check minimum number of events

None

7920

5. Include endpoints

None

7920

6. Filter based on genotype QC (FinnGen only)

7631

Control definitions (FinnGen only)

Control exclude N14_BREAST

Extra metadata

First used in FinnGen datafreeze DF8
Parent code in ICD-10 N60-N64
Name in latin Hypertrophia mammae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 47960 36263 11429
Only index persons 45671 35559 10112
Unadjusted period prevalence (%)
Whole population 0.86 1.04 0.32
Only index persons 1.10 1.31 0.39
Median age at first event (years)
Whole population 44.15 47.16 34.58
Only index persons 43.69 47.16 31.50

-FinnGen-

Key figures

All Female Male
Number of individuals 7631 6544 1087
Unadjusted period prevalence (%) 2.28 2.57 0.55
Median age at first event (years) 48.50 48.67 47.43

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_HYPERTROPHYBREAST_BOTH and mortality.

Females

Parameter HR [95% CI] p-value
N14_HYPERTROPHYBREAST_BOTH 0.898 [0.79, 1.02] 0.09
Birth year 1.0 [0.99, 1.01] 0.916

During the follow-up period (1.1.1998 — 31.12.2019), 1086 out of 28911 females with N14_HYPERTROPHYBREAST_BOTH died.

Males

Parameter HR [95% CI] p-value
N14_HYPERTROPHYBREAST_BOTH 1.2 [1.07, 1.34] 0.002
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1221 out of 7231 males with N14_HYPERTROPHYBREAST_BOTH died.

Mortality risk

Mortality risk for people of age

years, who have N14_HYPERTROPHYBREAST_BOTH.

N-year risk Females Males
1 0.104% 0.21%
5 0.606% 1.336%
10 1.501% 3.248%
15 2.892% 6.368%
20 5.099% 10.751%

Relationships between endpoints

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Index endpoint: N14_HYPERTROPHYBREAST_BOTH – Hypertrophy of breast in women and men

GWS hits: 24

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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