connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.
Systemic disorders of connective tissue in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
M13_SYSTCONINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
128 |
4. Check minimum number of eventsNone |
128 |
5. Include endpointsNone |
128 |
6. Filter based on genotype QC (FinnGen only) |
127 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Systemic disorders of connective tissue in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1422 | 617 | 803 |
| Only index persons | 1167 | 513 | 654 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 25.39 | 30.73 | 21.29 |
| Only index persons | 30.58 | 35.25 | 26.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 127 | 64 | 63 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 49.87 | 52.56 | 47.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTCONINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 5.224 [3.7, 7.37] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 560 females with M13_SYSTCONINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTCONINOTH | 3.748 [2.61, 5.38] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 723 males with M13_SYSTCONINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTCONINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.508% | 0.623% |
| 5 | 2.696% | 4.136% |
| 10 | 6.368% | 10.073% |
| 15 | 12.205% | 18.83% |
| 20 | 21.608% | 30.435% |
Relationships between endpoints
↥Index endpoint: M13_SYSTCONINOTH – Systemic disorders of connective tissue in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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