Rotator cuff syndrome

M13_ROTATORCUFF

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M75.1
  • Hospital discharge: ICD-9 7261X
  • Cause of death: ICD-10 M75.1
  • Cause of death: ICD-9 7261X

2 out of 7 registries used, show all original rules.

30473

4. Check minimum number of events

None

30473

5. Include endpoints

None

30473

6. Filter based on genotype QC (FinnGen only)

29524

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M75
Name in latin Syndroma armillae tendinum musculorum rotatorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 210716 100639 109422
Only index persons 203885 98531 105354
Unadjusted period prevalence (%)
Whole population 2.97 2.88 3.06
Only index persons 3.83 3.62 4.02
Median age at first event (years)
Whole population 55.40 55.35 55.47
Only index persons 55.29 55.24 55.34

-FinnGen-

Key figures

All Female Male
Number of individuals 29524 15199 14325
Unadjusted period prevalence (%) 6.56 5.97 7.19
Median age at first event (years) 55.64 54.58 56.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_ROTATORCUFF and mortality.

Females

Parameter HR [95% CI] p-value
M13_ROTATORCUFF 0.809 [0.74, 0.88] < 0.001
Birth year 0.997 [0.99, 1.0] 0.457

During the follow-up period (1.1.1998 — 31.12.2019), 7812 out of 84880 females with M13_ROTATORCUFF died.

Males

Parameter HR [95% CI] p-value
M13_ROTATORCUFF 0.765 [0.71, 0.83] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 11828 out of 92350 males with M13_ROTATORCUFF died.

Mortality risk

Mortality risk for people of age

years, who have M13_ROTATORCUFF.

N-year risk Females Males
1 0.08% 0.161%
5 0.503% 0.941%
10 1.275% 2.256%
15 2.421% 4.175%
20 4.348% 7.392%

Relationships between endpoints

Index endpoint: M13_ROTATORCUFF – Rotator cuff syndrome

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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