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Other specified/unspecified necrotizing vasculopathies

EFO MESH Endpoint Browser PheWeb

M13_NECROVASCNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.8, M31.9
  • Hospital discharge: ICD-9 — 447[5-6]
  • Hospital discharge: ICD-8 — 4469
  • Cause of death: ICD-10 — M31.8, M31.9
  • Cause of death: ICD-9 — 447[5-6]
  • Cause of death: ICD-8 — 4469

2 out of 7 registries used, show all original rules.

442

4. Check minimum number of events

None

442

5. Include endpoints

None

442

6. Filter based on genotype QC (FinnGen only)

430

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3624 1976 1609
Only index persons 2728 1510 1218
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.05 0.06 0.05
Median age at first event (years)
Whole population 61.78 62.38 60.96
Only index persons 59.20 59.37 58.98

-FinnGen-

Key figures

All Female Male
Number of individuals 430 233 197
Unadjusted period prevalence (%) 0.09 0.09 0.10
Median age at first event (years) 57.08 54.55 60.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint M13_NECROVASCNAS and mortality.

Females

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.738 [2.25, 3.33] < 0.001
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 1141 females with M13_NECROVASCNAS died.

Males

Parameter HR [95% CI] p-value
M13_NECROVASCNAS 2.719 [2.19, 3.38] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 382 out of 930 males with M13_NECROVASCNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_NECROVASCNAS.

N-year risk Females Males
1 0.155% 0.461%
5 1.405% 3.089%
10 3.493% 7.542%
15 7.111% 14.245%
20 12.552% 22.975%

Relationships between endpoints

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Index endpoint: M13_NECROVASCNAS – Other specified/unspecified necrotizing vasculopathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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