multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
201 |
4. Check minimum number of eventsNone |
201 |
5. Include endpointsNone |
201 |
6. Filter based on genotype QC (FinnGen only) |
196 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M35
Name in latin
Fibrosclerosis multifocalis
Similar endpoints
↥List of similar endpoints to
Multifocal fibrosclerosis
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1805 | 1278 | 511 |
| Only index persons | 1554 | 1106 | 448 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 72.13 | 72.44 | 71.18 |
| Only index persons | 70.74 | 71.06 | 69.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 196 | 134 | 62 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.03 |
| Median age at first event (years) | 63.05 | 60.93 | 67.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_MULTIFIBRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MULTIFIBRO | 1.619 [1.38, 1.9] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 1187 females with M13_MULTIFIBRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MULTIFIBRO | 1.371 [1.09, 1.72] | 0.006 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 481 males with M13_MULTIFIBRO died.
Mortality risk
Mortality risk for people of age
years, who have M13_MULTIFIBRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.27% |
| 5 | 0.745% | 1.63% |
| 10 | 1.866% | 3.975% |
| 15 | 3.45% | 7.504% |
| 20 | 6.278% | 13.11% |
Relationships between endpoints
↥Index endpoint: M13_MULTIFIBRO – Multifocal fibrosclerosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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