microscopic colitis: Inflammation of the colon that is only apparent by microscopic examination.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
171 |
4. Check minimum number of eventsNone |
171 |
5. Include endpointsNone |
171 |
6. Filter based on genotype QC (FinnGen only) |
166 |
Control definitions (FinnGen only)
Control exclude
M13_NECROVASC
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Similar endpoints
↥List of similar endpoints to
Microscopic polyangiitis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies (FG)
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 813 | 470 | 342 |
| Only index persons | 808 | 467 | 341 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 68.31 | 67.54 | 69.40 |
| Only index persons | 68.35 | 67.57 | 69.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 166 | 98 | 68 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 65.68 | 65.11 | 66.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_MICROPOLYANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MICROPOLYANG | 2.749 [1.87, 4.04] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.51 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 398 females with M13_MICROPOLYANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MICROPOLYANG | 2.227 [1.42, 3.48] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.08 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 278 males with M13_MICROPOLYANG died.
Mortality risk
Mortality risk for people of age
years, who have M13_MICROPOLYANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.3% | 0.427% |
| 5 | 1.814% | 2.869% |
| 10 | 4.159% | 6.919% |
| 15 | 8.407% | 12.425% |
| 20 | 14.379% | 21.206% |
Relationships between endpoints
↥Index endpoint: M13_MICROPOLYANG – Microscopic polyangiitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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