shoulder impingement syndrome: Compression of the rotator cuff tendons and subacromial bursa between the humeral head and structures that make up the coracoacromial arch and the humeral tuberosities. This condition is associated with subacromial bursitis and rotator cuff (largely supraspinatus) and bicipital tendon inflammation, with or without degenerative changes in the tendon. Pain that is most severe when the arm is abducted in an arc between 40 and 120 degrees, sometimes associated with tears in the rotator cuff, is the chief symptom. (From Jablonski's Dictionary of Syndromes and Eponymic Diseases, 2d ed)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
10513 |
4. Check minimum number of eventsNone |
10513 |
5. Include endpointsNone |
10513 |
6. Filter based on genotype QC (FinnGen only) |
10251 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M75
Name in latin
Syndroma angustiarum regionis deltoideae
Similar endpoints
↥List of similar endpoints to
Impingement syndrome of shoulder
based on the number of shared cases.
Similar with more cases:
- Shoulder lesions
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 71196 | 34860 | 36190 |
| Only index persons | 69775 | 34470 | 35305 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.00 | 1.00 | 1.01 |
| Only index persons | 1.31 | 1.27 | 1.35 |
| Median age at first event (years) | |||
| Whole population | 52.66 | 52.70 | 52.63 |
| Only index persons | 52.60 | 52.65 | 52.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10251 | 5536 | 4715 |
| Unadjusted period prevalence (%) | 2.26 | 2.17 | 2.37 |
| Median age at first event (years) | 53.11 | 52.08 | 54.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_IMPINGEMENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_IMPINGEMENT | 0.712 [0.65, 0.78] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.799 |
During the follow-up period (1.1.1998 — 31.12.2019), 1977 out of 33106 females with M13_IMPINGEMENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_IMPINGEMENT | 0.762 [0.7, 0.83] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 3529 out of 34481 males with M13_IMPINGEMENT died.
Mortality risk
Mortality risk for people of age
years, who have M13_IMPINGEMENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.072% | 0.131% |
| 5 | 0.433% | 0.845% |
| 10 | 1.203% | 2.165% |
| 15 | 2.292% | 4.11% |
| 20 | 4.023% | 7.094% |
Relationships between endpoints
↥Index endpoint: M13_IMPINGEMENT – Impingement syndrome of shoulder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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