No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1916 |
4. Check minimum number of eventsNone |
1916 |
5. Include endpointsNone |
1916 |
6. Filter based on genotype QC (FinnGen only) |
1859 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M35
Name in latin
Syndroma hypermobilitatis
Similar endpoints
↥List of similar endpoints to
Hypermobility syndrome
based on the number of shared cases.
Similar with more cases:
- Other systemic involvement of connective tissue (FG)
- Other systemic involvement of connective tissue
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12843 | 11010 | 1784 |
| Only index persons | 12485 | 10796 | 1689 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.32 | 0.05 |
| Only index persons | 0.35 | 0.40 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 34.47 | 36.00 | 25.00 |
| Only index persons | 34.85 | 36.20 | 26.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1859 | 1728 | 131 |
| Unadjusted period prevalence (%) | 0.64 | 0.68 | 0.07 |
| Median age at first event (years) | 38.34 | 38.33 | 38.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_HYPERMOBILITY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERMOBILITY | 0.823 [0.69, 0.99] | 0.036 |
| Birth year | 0.995 [0.99, 1.0] | 0.279 |
During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 10095 females with M13_HYPERMOBILITY died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_HYPERMOBILITY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.072% | No data |
| 5 | 0.416% | No data |
| 10 | 1.087% | No data |
| 15 | 2.289% | No data |
| 20 | 4.021% | No data |
Relationships between endpoints
↥Index endpoint: M13_HYPERMOBILITY – Hypermobility syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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