hypersensitivity vasculitis: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
164 |
4. Check minimum number of eventsNone |
164 |
5. Include endpointsNone |
164 |
6. Filter based on genotype QC (FinnGen only) |
160 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Angi(i)tis hypersensitivitatis
Similar endpoints
↥List of similar endpoints to
Hypersensitivity angiitis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1066 | 579 | 476 |
| Only index persons | 811 | 452 | 359 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 60.49 | 61.23 | 59.53 |
| Only index persons | 57.92 | 58.46 | 57.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 160 | 82 | 78 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 57.70 | 56.09 | 59.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_HYPERANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERANG | 3.134 [2.31, 4.24] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.178 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 383 females with M13_HYPERANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HYPERANG | 2.479 [1.81, 3.4] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 304 males with M13_HYPERANG died.
Mortality risk
Mortality risk for people of age
years, who have M13_HYPERANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.298% | 0.555% |
| 5 | 1.629% | 3.059% |
| 10 | 4.34% | 7.777% |
| 15 | 7.969% | 14.342% |
| 20 | 13.634% | 23.512% |
Relationships between endpoints
↥Index endpoint: M13_HYPERANG – Hypersensitivity angiitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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