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Thrombotic microangiopathy

DOID EFO Endpoint Browser PheWeb

M13_HTROMBMICROANG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M31.1
  • Hospital discharge: ICD-9 — 4466
  • Hospital discharge: ICD-8 — 4464
  • Cause of death: ICD-10 — M31.1
  • Cause of death: ICD-9 — 4466
  • Cause of death: ICD-8 — 4464

2 out of 7 registries used, show all original rules.

202

4. Check minimum number of events

None

202

5. Include endpoints

None

202

6. Filter based on genotype QC (FinnGen only)

193

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M31
Name in latin Microangiopathia thrombotica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1214 706 498
Only index persons 1034 606 428
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 56.61 55.13 58.60
Only index persons 55.82 54.53 57.64

-FinnGen-

Key figures

All Female Male
Number of individuals 193 112 81
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 53.78 51.47 56.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint M13_HTROMBMICROANG and mortality.

Females

Parameter HR [95% CI] p-value
M13_HTROMBMICROANG 3.027 [2.31, 3.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.064

During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 569 females with M13_HTROMBMICROANG died.

Males

Parameter HR [95% CI] p-value
M13_HTROMBMICROANG 2.429 [1.94, 3.05] < 0.001
Birth year 0.991 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 411 males with M13_HTROMBMICROANG died.

Mortality risk

Mortality risk for people of age

years, who have M13_HTROMBMICROANG.

N-year risk Females Males
1 0.267% 0.436%
5 1.504% 2.909%
10 3.987% 7.723%
15 7.418% 14.785%
20 12.635% 24.923%

Relationships between endpoints

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Index endpoint: M13_HTROMBMICROANG – Thrombotic microangiopathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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