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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Diffuse (eosinophilic) fasciitis

M13_DIFFASCITIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M35.4
  • Cause of death: ICD-10 M35.4

2 out of 7 registries used, show all original rules.

45

4. Check minimum number of events

None

45

5. Include endpoints

None

45

6. Filter based on genotype QC (FinnGen only)

45

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Fasci[i]tis [eosinophila] diffusa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 308 198 108
Only index persons 287 185 102
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 58.90 60.24 56.13
Only index persons 56.83 58.34 54.10

-FinnGen-

Key figures

All Female Male
Number of individuals 45 31 14
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 57.90 57.01 59.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint M13_DIFFASCITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_DIFFASCITIS 1.827 [1.31, 2.54] < 0.001
Birth year 0.992 [0.98, 1.0] 0.086

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 174 females with M13_DIFFASCITIS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_DIFFASCITIS.

N-year risk Females Males
1 0.141% No data
5 0.953% No data
10 2.411% No data
15 4.638% No data
20 8.067% No data

Relationships between endpoints

Index endpoint: M13_DIFFASCITIS – Diffuse (eosinophilic) fasciitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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