Calcific tendinitis of shoulder

M13_CALCIFICTEND

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M75.3
  • Hospital discharge: ICD-9 7261A
  • Cause of death: ICD-10 M75.3
  • Cause of death: ICD-9 7261A

2 out of 7 registries used, show all original rules.

2149

4. Check minimum number of events

None

2149

5. Include endpoints

None

2149

6. Filter based on genotype QC (FinnGen only)

2080

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M75
Name in latin Tendo calcificans regionis deltoideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13895 8889 4957
Only index persons 13375 8698 4677
Unadjusted period prevalence (%)
Whole population 0.21 0.25 0.14
Only index persons 0.27 0.32 0.18
Median age at first event (years)
Whole population 50.85 50.75 51.04
Only index persons 50.72 50.68 50.80

-FinnGen-

Key figures

All Female Male
Number of individuals 2080 1426 654
Unadjusted period prevalence (%) 0.49 0.56 0.33
Median age at first event (years) 50.95 50.23 52.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_CALCIFICTEND and mortality.

Females

Parameter HR [95% CI] p-value
M13_CALCIFICTEND 0.703 [0.6, 0.82] < 0.001
Birth year 0.994 [0.99, 1.0] 0.191

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 6721 females with M13_CALCIFICTEND died.

Males

Parameter HR [95% CI] p-value
M13_CALCIFICTEND 0.85 [0.74, 0.98] 0.028
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 281 out of 3510 males with M13_CALCIFICTEND died.

Mortality risk

Mortality risk for people of age

years, who have M13_CALCIFICTEND.

N-year risk Females Males
1 0.07% 0.15%
5 0.424% 0.992%
10 0.991% 2.365%
15 1.956% 4.545%
20 3.591% 7.657%

Relationships between endpoints

Index endpoint: M13_CALCIFICTEND – Calcific tendinitis of shoulder

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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