Synovial cyst of popliteal space [Baker]

M13_BAKERCYST

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M71.2
  • Hospital discharge: ICD-9 7275A
  • Cause of death: ICD-10 M71.2
  • Cause of death: ICD-9 7275A

2 out of 7 registries used, show all original rules.

2688

4. Check minimum number of events

None

2688

5. Include endpoints

None

2688

6. Filter based on genotype QC (FinnGen only)

2607

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M71
Name in latin Cysta synovialis spatii poplitealis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21745 13464 8209
Only index persons 20229 12655 7574
Unadjusted period prevalence (%)
Whole population 0.33 0.39 0.23
Only index persons 0.40 0.47 0.29
Median age at first event (years)
Whole population 59.37 61.88 55.21
Only index persons 58.77 61.23 54.66

-FinnGen-

Key figures

All Female Male
Number of individuals 2607 1637 970
Unadjusted period prevalence (%) 0.58 0.64 0.49
Median age at first event (years) 59.38 58.93 60.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_BAKERCYST and mortality.

Females

Parameter HR [95% CI] p-value
M13_BAKERCYST 0.985 [0.89, 1.09] 0.764
Birth year 0.996 [0.99, 1.0] 0.36

During the follow-up period (1.1.1998 — 31.12.2019), 2109 out of 10644 females with M13_BAKERCYST died.

Males

Parameter HR [95% CI] p-value
M13_BAKERCYST 0.968 [0.86, 1.09] 0.588
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1076 out of 6144 males with M13_BAKERCYST died.

Mortality risk

Mortality risk for people of age

years, who have M13_BAKERCYST.

N-year risk Females Males
1 0.111% 0.195%
5 0.598% 1.069%
10 1.616% 2.701%
15 2.998% 4.748%
20 5.247% 7.925%

Relationships between endpoints

Index endpoint: M13_BAKERCYST – Synovial cyst of popliteal space [Baker]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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