No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7912 |
4. Check minimum number of eventsNone |
7912 |
5. Include endpointsNone |
7912 |
6. Filter based on genotype QC (FinnGen only) |
7713 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M15-M19
Name in latin
Polyarthrosis
Similar endpoints
↥List of similar endpoints to
Polyarthrosis
based on the number of shared cases.
Similar with more cases:
- Arthrosis
- Artrosis, including avohilmo
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 75747 | 58807 | 16522 |
| Only index persons | 62833 | 49758 | 13075 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.41 | 1.68 | 0.46 |
| Only index persons | 1.55 | 1.83 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 70.65 | 70.92 | 69.74 |
| Only index persons | 69.25 | 69.56 | 68.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7713 | 5863 | 1850 |
| Unadjusted period prevalence (%) | 1.97 | 2.30 | 0.93 |
| Median age at first event (years) | 63.79 | 62.99 | 66.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHROSIS_POLY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS_POLY | 1.311 [1.18, 1.46] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.247 |
During the follow-up period (1.1.1998 — 31.12.2019), 11675 out of 40831 females with M13_ARTHROSIS_POLY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS_POLY | 1.31 [1.14, 1.51] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 3479 out of 10812 males with M13_ARTHROSIS_POLY died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHROSIS_POLY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | 0.196% |
| 5 | 0.689% | 1.372% |
| 10 | 1.947% | 3.739% |
| 15 | 3.764% | 7.003% |
| 20 | 6.249% | 12.017% |
Relationships between endpoints
↥Index endpoint: M13_ARTHROSIS_POLY – Polyarthrosis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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