frozen shoulder: Inflammation or irritation of a bursa, the fibrous sac that acts as a cushion between moving structures of bones, muscles, tendons or skin.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6910 |
4. Check minimum number of eventsNone |
6910 |
5. Include endpointsNone |
6910 |
6. Filter based on genotype QC (FinnGen only) |
6666 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M75
Name in latin
Capsulitis adhaesiva articulationis humeri
Similar endpoints
↥List of similar endpoints to
Adhesive capsulitis of shoulder
based on the number of shared cases.
Similar with more cases:
- Shoulder lesions
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 47916 | 26714 | 20956 |
| Only index persons | 44165 | 25376 | 18789 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.68 | 0.77 | 0.59 |
| Only index persons | 0.84 | 0.93 | 0.72 |
| Median age at first event (years) | |||
| Whole population | 54.19 | 53.52 | 54.99 |
| Only index persons | 53.68 | 53.18 | 54.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6666 | 4020 | 2646 |
| Unadjusted period prevalence (%) | 1.48 | 1.58 | 1.33 |
| Median age at first event (years) | 53.61 | 52.57 | 55.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ADHCAPSULITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ADHCAPSULITIS | 0.963 [0.88, 1.06] | 0.42 |
| Birth year | 0.999 [0.99, 1.01] | 0.876 |
During the follow-up period (1.1.1998 — 31.12.2019), 1805 out of 19890 females with M13_ADHCAPSULITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ADHCAPSULITIS | 0.913 [0.84, 0.99] | 0.031 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 2465 out of 15640 males with M13_ADHCAPSULITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_ADHCAPSULITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.216% |
| 5 | 0.64% | 1.095% |
| 10 | 1.48% | 2.74% |
| 15 | 3.006% | 5.128% |
| 20 | 5.514% | 8.979% |
Relationships between endpoints
↥Index endpoint: M13_ADHCAPSULITIS – Adhesive capsulitis of shoulder
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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