rosacea: a chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2886 |
4. Check minimum number of eventsNone |
2886 |
5. Include endpointsNone |
2886 |
6. Filter based on genotype QC (FinnGen only) |
2808 |
Control definitions (FinnGen only)
Control exclude
L12_DISORDSKINAPPENDIX
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified rosacea
based on the number of shared cases.
Similar with more cases:
- Rosacea
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18076 | 11991 | 6018 |
| Only index persons | 17470 | 11760 | 5710 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.34 | 0.17 |
| Only index persons | 0.36 | 0.43 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 54.55 | 52.63 | 58.42 |
| Only index persons | 54.37 | 52.49 | 58.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2808 | 1958 | 850 |
| Unadjusted period prevalence (%) | 0.67 | 0.77 | 0.43 |
| Median age at first event (years) | 55.40 | 52.74 | 61.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ROSACEANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ROSACEANAS | 1.025 [0.91, 1.15] | 0.679 |
| Birth year | 0.993 [0.98, 1.0] | 0.116 |
During the follow-up period (1.1.1998 — 31.12.2019), 841 out of 9572 females with L12_ROSACEANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ROSACEANAS | 1.159 [1.02, 1.31] | 0.02 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 4958 males with L12_ROSACEANAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_ROSACEANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.201% |
| 5 | 0.63% | 1.099% |
| 10 | 1.48% | 2.94% |
| 15 | 3.042% | 5.396% |
| 20 | 4.96% | 9.137% |
Relationships between endpoints
↥Index endpoint: L12_ROSACEANAS – Other and unspecified rosacea
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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