acrodermatitis: An inflammatory skin condition affecting children. It is often associated with Epstein-Barr virus infection, hepatitis B infection or cytomegalovirus infection. It is characterized by the presence of cutaneous rashes and patches on the palms and soles. The trunk is not affected.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
72 |
4. Check minimum number of eventsNone |
72 |
5. Include endpointsNone |
72 |
6. Filter based on genotype QC (FinnGen only) |
69 |
Control definitions (FinnGen only)
Control exclude
L12_RADIATIONRELATEDSKIN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L55-L59
Name in latin
Radiodermatitis
Similar endpoints
↥List of similar endpoints to
Radiodermatitis
based on the number of shared cases.
Similar with more cases:
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 430 | 304 | 124 |
| Only index persons | 380 | 272 | 108 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 61.07 | 62.40 | 57.84 |
| Only index persons | 60.71 | 62.23 | 56.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 52 | 17 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 59.31 | 59.74 | 57.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_RADIODERMATITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_RADIODERMATITIS | 1.892 [1.32, 2.71] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.171 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 262 females with L12_RADIODERMATITIS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_RADIODERMATITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | No data |
| 5 | 1.015% | No data |
| 10 | 2.571% | No data |
| 15 | 5.165% | No data |
| 20 | 9.201% | No data |
Relationships between endpoints
↥Index endpoint: L12_RADIODERMATITIS – Radiodermatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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