No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
298 |
4. Check minimum number of eventsNone |
298 |
5. Include endpointsNone |
298 |
6. Filter based on genotype QC (FinnGen only) |
289 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L81
Name in latin
Purpura pigmentosa
Similar endpoints
↥List of similar endpoints to
Pigmented purpuric dermatosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2176 | 1158 | 1011 |
| Only index persons | 2090 | 1132 | 958 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.25 | 60.79 | 57.46 |
| Only index persons | 59.00 | 60.61 | 57.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 289 | 157 | 132 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | 59.29 | 59.27 | 59.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_PIGPURPDERM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PIGPURPDERM | 0.86 [0.69, 1.07] | 0.17 |
| Birth year | 0.995 [0.99, 1.0] | 0.213 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 992 females with L12_PIGPURPDERM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PIGPURPDERM | 1.032 [0.84, 1.26] | 0.763 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 884 males with L12_PIGPURPDERM died.
Mortality risk
Mortality risk for people of age
years, who have L12_PIGPURPDERM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.118% | 0.185% |
| 5 | 0.529% | 1.12% |
| 10 | 1.299% | 2.87% |
| 15 | 2.442% | 5.331% |
| 20 | 4.198% | 9.065% |
Relationships between endpoints
↥Index endpoint: L12_PIGPURPDERM – Pigmented purpuric dermatosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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