rosacea: a chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
700 |
4. Check minimum number of eventsNone |
700 |
5. Include endpointsNone |
700 |
6. Filter based on genotype QC (FinnGen only) |
680 |
Control definitions (FinnGen only)
Control exclude
L12_DISORDSKINAPPENDIX
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L71
Name in latin
Dermatitis perioralis
Similar endpoints
↥List of similar endpoints to
Perioral dermatitis
based on the number of shared cases.
Similar with more cases:
- Rosacea
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4435 | 3704 | 720 |
| Only index persons | 4253 | 3606 | 647 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.02 |
| Only index persons | 0.12 | 0.13 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 40.59 | 40.25 | 42.27 |
| Only index persons | 40.98 | 40.43 | 44.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 680 | 611 | 69 |
| Unadjusted period prevalence (%) | 0.22 | 0.24 | 0.03 |
| Median age at first event (years) | 45.95 | 44.92 | 55.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_PERIORALDERM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PERIORALDERM | 0.904 [0.74, 1.1] | 0.316 |
| Birth year | 0.996 [0.99, 1.0] | 0.35 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 2529 females with L12_PERIORALDERM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PERIORALDERM | 1.434 [1.09, 1.89] | 0.011 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 585 males with L12_PERIORALDERM died.
Mortality risk
Mortality risk for people of age
years, who have L12_PERIORALDERM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.262% |
| 5 | 0.583% | 1.442% |
| 10 | 1.383% | 3.6% |
| 15 | 2.476% | 7.047% |
| 20 | 4.8% | 12.19% |
Relationships between endpoints
↥Index endpoint: L12_PERIORALDERM – Perioral dermatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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