pemphigus vulgaris: Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
69 |
4. Check minimum number of eventsNone |
69 |
5. Include endpointsNone |
69 |
6. Filter based on genotype QC (FinnGen only) |
67 |
Control definitions (FinnGen only)
Control exclude
L12_BULLOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L10
Name in latin
Pemphigus vulgaris
Similar endpoints
↥List of similar endpoints to
Pemphigus vulgaris
based on the number of shared cases.
Similar with more cases:
- Pemphigus
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 640 | 359 | 278 |
| Only index persons | 523 | 299 | 224 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 60.66 | 64.02 | 56.61 |
| Only index persons | 57.85 | 60.55 | 54.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 67 | 40 | 27 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 60.86 | 57.65 | 65.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGUS_VULG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGUS_VULG | 1.752 [1.25, 2.45] | 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.182 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 304 females with L12_PEMPHIGUS_VULG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGUS_VULG | 1.904 [1.16, 3.12] | 0.011 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 246 males with L12_PEMPHIGUS_VULG died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGUS_VULG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.421% |
| 5 | 0.95% | 2.362% |
| 10 | 2.56% | 5.591% |
| 15 | 4.683% | 10.843% |
| 20 | 8.381% | 17.73% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGUS_VULG – Pemphigus vulgaris
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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