phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
DOID EFO Endpoint Browser PheWeb
L12_NONIONRADISKINNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
427 |
4. Check minimum number of eventsNone |
427 |
5. Include endpointsNone |
427 |
6. Filter based on genotype QC (FinnGen only) |
412 |
Control definitions (FinnGen only)
Control exclude
L12_RADIATIONRELATEDSKIN
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
based on the number of shared cases.
Similar with more cases:
- Skin changes due to chronic exposure to nonionizing radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3420 | 1992 | 1406 |
| Only index persons | 3066 | 1831 | 1235 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 71.86 | 71.91 | 71.77 |
| Only index persons | 71.03 | 71.15 | 70.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 412 | 210 | 202 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.10 |
| Median age at first event (years) | 67.66 | 65.34 | 70.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_NONIONRADISKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.839 [0.75, 0.94] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 659 out of 1855 females with L12_NONIONRADISKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.902 [0.79, 1.03] | 0.133 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 578 out of 1306 males with L12_NONIONRADISKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NONIONRADISKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.162% |
| 5 | 0.522% | 0.98% |
| 10 | 1.337% | 2.459% |
| 15 | 2.522% | 4.826% |
| 20 | 4.316% | 8.193% |
Relationships between endpoints
↥Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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