osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1959 |
4. Check minimum number of eventsNone |
1959 |
5. Include endpointsNone |
1959 |
6. Filter based on genotype QC (FinnGen only) |
1866 |
Control definitions (FinnGen only)
Control exclude
L12_OTHERSKINSUBCUTIS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L91
Name in latin
Cicatrix cheloides
Similar endpoints
↥List of similar endpoints to
Hypertrophic scar
based on the number of shared cases.
Similar with more cases:
- Hypertrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16484 | 10557 | 5801 |
| Only index persons | 15658 | 10196 | 5462 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.30 | 0.16 |
| Only index persons | 0.32 | 0.37 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 30.18 | 31.04 | 28.53 |
| Only index persons | 29.89 | 30.87 | 28.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1866 | 1370 | 496 |
| Unadjusted period prevalence (%) | 0.46 | 0.54 | 0.25 |
| Median age at first event (years) | 38.86 | 37.16 | 43.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_HYPETROPHICSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HYPETROPHICSCAR | 1.08 [0.94, 1.24] | 0.262 |
| Birth year | 0.994 [0.99, 1.0] | 0.164 |
During the follow-up period (1.1.1998 — 31.12.2019), 459 out of 8358 females with L12_HYPETROPHICSCAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HYPETROPHICSCAR | 1.039 [0.9, 1.2] | 0.601 |
| Birth year | 0.989 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 412 out of 4644 males with L12_HYPETROPHICSCAR died.
Mortality risk
Mortality risk for people of age
years, who have L12_HYPETROPHICSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.281% |
| 5 | 0.609% | 1.569% |
| 10 | 1.573% | 3.594% |
| 15 | 3.011% | 6.578% |
| 20 | 5.302% | 10.837% |
Relationships between endpoints
↥Index endpoint: L12_HYPETROPHICSCAR – Hypertrophic scar
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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