Other and unspecified nonscarring hair loss

L12_HAIRLOSS_NONSCARNAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

212

4. Check minimum number of events

None

212

5. Include endpoints

None

212

6. Filter based on genotype QC (FinnGen only)

200

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1676 1527 142
Only index persons 1591 1465 126
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.00
Only index persons 0.05 0.05 0.00
Median age at first event (years)
Whole population 38.60 40.48 18.66
Only index persons 39.71 41.33 20.91

-FinnGen-

Key figures

All Female Male
Number of individuals 200 197 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 44.36 44.52 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint L12_HAIRLOSS_NONSCARNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_HAIRLOSS_NONSCARNAS 1.264 [0.93, 1.72] 0.139
Birth year 0.996 [0.99, 1.0] 0.376

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1161 females with L12_HAIRLOSS_NONSCARNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_HAIRLOSS_NONSCARNAS.

N-year risk Females Males
1 0.148% No data
5 0.788% No data
10 1.975% No data
15 3.802% No data
20 6.515% No data

Relationships between endpoints

Index endpoint: L12_HAIRLOSS_NONSCARNAS – Other and unspecified nonscarring hair loss

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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