Erythema intertrigo

L12_ERYT_INTERTRIG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L30.4
  • Hospital discharge: ICD-9 6958A
  • Cause of death: ICD-10 L30.4
  • Cause of death: ICD-9 6958A

2 out of 7 registries used, show all original rules.

735

4. Check minimum number of events

None

735

5. Include endpoints

None

735

6. Filter based on genotype QC (FinnGen only)

718

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L30
Name in latin Intertrigo

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5579 2921 2627
Only index persons 4898 2577 2321
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.07
Only index persons 0.09 0.09 0.09
Median age at first event (years)
Whole population 62.82 66.01 59.27
Only index persons 62.54 65.75 58.99

-FinnGen-

Key figures

All Female Male
Number of individuals 718 388 330
Unadjusted period prevalence (%) 0.16 0.15 0.17
Median age at first event (years) 64.19 64.30 64.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint L12_ERYT_INTERTRIG and mortality.

Females

Parameter HR [95% CI] p-value
L12_ERYT_INTERTRIG 2.082 [1.74, 2.5] < 0.001
Birth year 0.995 [0.99, 1.0] 0.21

During the follow-up period (1.1.1998 — 31.12.2019), 658 out of 2206 females with L12_ERYT_INTERTRIG died.

Males

Parameter HR [95% CI] p-value
L12_ERYT_INTERTRIG 2.077 [1.71, 2.52] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 541 out of 1988 males with L12_ERYT_INTERTRIG died.

Mortality risk

Mortality risk for people of age

years, who have L12_ERYT_INTERTRIG.

N-year risk Females Males
1 0.15% 0.422%
5 1.139% 2.249%
10 3.01% 5.505%
15 5.663% 10.374%
20 9.833% 17.067%

Relationships between endpoints

Index endpoint: L12_ERYT_INTERTRIG – Erythema intertrigo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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