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Dyshidrosis [pompholyx]

DOID EFO Endpoint Browser PheWeb

L12_DYSHIDROSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L30.1
  • Hospital discharge: ICD-9 — 7058A
  • Hospital discharge: ICD-8 — 69283
  • Cause of death: ICD-10 — L30.1
  • Cause of death: ICD-9 — 7058A
  • Cause of death: ICD-8 — 69283

2 out of 7 registries used, show all original rules.

532

4. Check minimum number of events

None

532

5. Include endpoints

None

532

6. Filter based on genotype QC (FinnGen only)

514

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L30
Name in latin Pompholyx

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3645 2184 1440
Only index persons 3395 2092 1303
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.07 0.08 0.05
Median age at first event (years)
Whole population 39.06 39.22 38.77
Only index persons 38.66 38.88 38.32

-FinnGen-

Key figures

All Female Male
Number of individuals 514 352 162
Unadjusted period prevalence (%) 0.12 0.14 0.08
Median age at first event (years) 42.88 42.24 44.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_DYSHIDROSIS and mortality.

Females

Parameter HR [95% CI] p-value
L12_DYSHIDROSIS 1.254 [0.92, 1.71] 0.15
Birth year 0.999 [0.99, 1.01] 0.788

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 1569 females with L12_DYSHIDROSIS died.

Males

Parameter HR [95% CI] p-value
L12_DYSHIDROSIS 1.603 [1.25, 2.06] < 0.001
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 941 males with L12_DYSHIDROSIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_DYSHIDROSIS.

N-year risk Females Males
1 0.106% 0.215%
5 0.884% 1.593%
10 2.169% 4.084%
15 3.959% 7.696%
20 7.136% 13.227%

Relationships between endpoints

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Index endpoint: L12_DYSHIDROSIS – Dyshidrosis [pompholyx]

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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