dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
601 |
4. Check minimum number of eventsNone |
601 |
5. Include endpointsNone |
601 |
6. Filter based on genotype QC (FinnGen only) |
585 |
Control definitions (FinnGen only)
Control exclude
L12_BULLOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L13
Name in latin
Dermatitis herpetiformis
Similar endpoints
↥List of similar endpoints to
Dermatitis herpetiformis
based on the number of shared cases.
Similar with more cases:
- Other bullous disorders
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4875 | 2511 | 2338 |
| Only index persons | 4281 | 2269 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 45.74 | 45.97 | 45.38 |
| Only index persons | 44.15 | 44.66 | 43.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 585 | 333 | 252 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | 45.47 | 41.92 | 50.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_DERMATHERP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DERMATHERP | 0.983 [0.85, 1.14] | 0.828 |
| Birth year | 0.994 [0.99, 1.0] | 0.152 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1738 females with L12_DERMATHERP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DERMATHERP | 0.935 [0.82, 1.07] | 0.33 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 281 out of 1496 males with L12_DERMATHERP died.
Mortality risk
Mortality risk for people of age
years, who have L12_DERMATHERP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.172% |
| 5 | 0.593% | 1.034% |
| 10 | 1.418% | 2.787% |
| 15 | 2.79% | 5.294% |
| 20 | 4.949% | 8.632% |
Relationships between endpoints
↥Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data