subcorneal pustular dermatosis: a rare, benign, chronic relapsing sterile pustular eruption typically involving the flexural sites of the trunk and proximal extremities. It most commonly affects woman aged 40 years or older.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
764 |
4. Check minimum number of eventsNone |
764 |
5. Include endpoints |
885 |
6. Filter based on genotype QC (FinnGen only) |
860 |
Control definitions (FinnGen only)
Control exclude
L12_BULLOUS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L10-L14
Name in latin
Aliae morbositates bullosae
Similar endpoints
↥List of similar endpoints to
Other bullous disorders
based on the number of shared cases.
Similar with more cases:
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7656 | 4036 | 3577 |
| Only index persons | 6569 | 3572 | 2997 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.10 |
| Only index persons | 0.12 | 0.13 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 48.42 | 48.66 | 48.09 |
| Only index persons | 47.51 | 47.64 | 47.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 860 | 496 | 364 |
| Unadjusted period prevalence (%) | 0.19 | 0.19 | 0.18 |
| Median age at first event (years) | 49.35 | 46.27 | 53.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_BULLOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOTH | 1.288 [1.11, 1.49] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.879 |
During the follow-up period (1.1.1998 — 31.12.2019), 519 out of 2922 females with L12_BULLOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOTH | 1.22 [1.06, 1.4] | 0.006 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 2437 males with L12_BULLOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_BULLOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.243% |
| 5 | 0.847% | 1.526% |
| 10 | 2.264% | 3.883% |
| 15 | 4.52% | 7.531% |
| 20 | 7.761% | 13.074% |
Relationships between endpoints
↥Index endpoint: L12_BULLOTH – Other bullous disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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