allergic contact dermatitis: An inflammatory skin condition caused by an immune response to direct contact between the skin and an allergen. It consists of a delayed type of allergic reaction at the affected site with resulting red, swollen, and blistered skin that may itch or leak.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5511 |
4. Check minimum number of eventsNone |
5511 |
5. Include endpointsNone |
5511 |
6. Filter based on genotype QC (FinnGen only) |
5331 |
Control definitions (FinnGen only)
Control exclude
L12_DERMATITISECZEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L20-L30
Name in latin
Eczema (allergicum) ex contactu
Similar endpoints
↥List of similar endpoints to
Allergic contact dermatitis
based on the number of shared cases.
Similar with more cases:
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 43120 | 31110 | 11862 |
| Only index persons | 41106 | 30055 | 11051 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.73 | 0.89 | 0.33 |
| Only index persons | 0.92 | 1.10 | 0.42 |
| Median age at first event (years) | |||
| Whole population | 44.15 | 44.70 | 42.75 |
| Only index persons | 44.01 | 44.48 | 42.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5331 | 4172 | 1159 |
| Unadjusted period prevalence (%) | 1.41 | 1.64 | 0.58 |
| Median age at first event (years) | 47.80 | 46.59 | 52.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ALLERGICCONTACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALLERGICCONTACT | 0.967 [0.87, 1.07] | 0.537 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 1885 out of 27327 females with L12_ALLERGICCONTACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALLERGICCONTACT | 1.022 [0.92, 1.14] | 0.698 |
| Birth year | 0.987 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1054 out of 10081 males with L12_ALLERGICCONTACT died.
Mortality risk
Mortality risk for people of age
years, who have L12_ALLERGICCONTACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.198% |
| 5 | 0.533% | 1.186% |
| 10 | 1.338% | 2.921% |
| 15 | 2.52% | 5.536% |
| 20 | 4.343% | 9.566% |
Relationships between endpoints
↥Index endpoint: L12_ALLERGICCONTACT – Allergic contact dermatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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